Matthew Stafford threw two of his four touchdown passes to Calvin Johnson on Sunday as the Lions routed the Kansas City Chiefs48-3, the largest margin of victory in franchise history.
Detroit broke its record, set with a 44-0 win over the expansion Jacksonville Jaguars in 1995.
The Lions (2-0) led the Chiefs 20-3 at halftime and 41-3 early in the fourth quarter after turning two fumbles into TDs.
The Chiefs (0-2) lost more than just the game, coming off a 34-point loss at home to the Buffalo Bills. Running back Jamaal Charles was carted off the field midway through the first quarter with an injured left knee.
Pro Bowl safety Eric Berry and tight end Tony Moeaki already are on season-ending injured reserve for Kansas City with knee injuries.
